NORMAN

Collaborative Trials

2020-2022: Interlab study on Non-target and suspect screening methods for organic substances in indoor dust (ILS-NTS_Dust2) (Umea University and NILU).

2019-2021: Interlab study on NTS of CECs in biota after a Workshop on NTS in biota (Uppsala 2018) using environmental specimen banks archived samples.

2019-2021: Interlab study on Passive sampling & evaluation of algorithms for deconvolution and library-searching, the data are published in Scientific Data.

2015-2016: Collaborative Trial on non-target screening techniques on dust samples: This CT was organised in collaboration with the WG Indoor environment. The results are published in Analytical and Bioanalytical Chemistry.

2013: Collaborative Trial on non-target screening techniques applied to a river water sample: This was the first time worldwidesuch an exercise had been conducted in the area of environmental analysis. The results are published in Analytical and Bioanalytical Chemistry.

Retrospective screening tools

NormaNEWS2 (Second round of the NORMAN network Early Warning System initiative) was launched in 2019. The participants selected a NormaNEWS2 list of suspects (> 300 compounds) which has been added to the Suspect List Exchange page (DOI: 10.5281/zenodo.3634963) and is now part of SusDat and EPA CompTox Dashboard. All results were submitted and the results are currently evaluated.

NORMAN Suspect List Exchange initiative and SusDat database: The aim of this initiative is to share information on substances and associated metadata from different platforms, as a common effort of European and North American researchers to support contaminant identification, prioritisation and retrospective screening efforts. All suspect lists are integrated into the US EPA CompTox Chemistry Dashboard. All suspect lists can be found on Zenodo. DOI: 10.5281/zenodo.4249026.

NormaNEWS (The Norman Early Warning System): was launched in 2015 to test the potential of an “Early warning network” to rapidly assess the spatial and temporal distribution of contaminants of emerging concern in environmental samples through retrospective analysis of HRMS data. The results of the first round of NormaNEWS are published in Environ. Sci. & Technology. 

NORMAN RTI (Retention Time Index): was developed as a harmonised model for the prediction of the retention time index (RTI) for more robust retrospective analysis of a large number of contaminants of emerging concern. Publication in prep.

NORMAN MassBank: was launched in 2011 as a web-based open access mass spectral database for all kinds of high- and low-resolution mass spectra (e.g. EI-MS, QToF-MSMS, FTMS). 

The NORMAN Digital Sample Freezing Platform (NORMAN DSFP) has been developed to host in a harmonised format liquid chromatography high resolution-mass spectrometry (LC-HR-MS) data, allowing for high-throughput processing, including retrospective analysis, of environmental samples for a wide range (thousands) of pollutants. Options for ‘big data’ processing/exchange at the European scale is being tested. Publication in prep.

Past events / workshops

• 14-15.05.2019 - Expert meeting with WG-1 Prioritisation to improve the current NORMAN Prioritisation Framework and allow more exhaustive analysis of the current status of knowledge for a large list of chemicals (SusDat list) in Paris
• Workshop on Reference materials for NTS (Wageningen Environmental Research - Alterra) 
• Workshop on passive sampling and NTS (NIVA)
• 25.10.2018 - NTS workshop on Non-Target Screening for Regulators: How can non-target screening techniques support environmental monitoring and chemicals management? The results have been summarized in a publication in Environmental Sciences Europe (2019)
• 16.-17.10.2018 - Discussion group on NTS in biota using environmental specimen banks archives for the identification of CECs (SLU) in Uppsala
• 22.06.2017 - NORMAN Satellite Event on Current Status & Developments in Suspect and Non-target Screening linked to the 16th International Conference on Chemistry and the Environment (ICCE) in Oslo
• 02.09.2015 - The official NTS Group kick-off meeting took place in Rhodes, Greece (meeting report)
• 16-17.09.2014 - Workshop on Non-Target Screening: Towards the harmonisation of methods for non-target screening of environmental samples 
• 17-18.09.2014 - NORMAN MassBank Workshop
• 15-16.09.2014 - NORMAN Collaborative Screening Trial Workshop for participants

Publications

• R. Aalizadeh, N.A. Alygizakis, E. Schymanski, M. Krauss, T. Schulze, M. Ibáñez, A.D. McEachran, A. Chao, A.J. Williams, P. Gago-Ferrero, A. Covaci, C. Moschet, T. Young, J. Hollender, J. Slobodnik, N.Thomaidis, Development and Application of Liquid Chromatographic Retention Time Indices in HRMS-based Suspect and Non-target Screening, Analytical Chemistry (2021). 
• B. Schulze, D. van Herwerden, I. Allan, L. Bijlsma, N. Etxebarria, M. Hansen, S. Merel, B. Vrana, R. Aalizadeh, B. Bajema, F. Dubocq, G. Coppola, A. Fildier, P. Fialová, E. Frøkjær, R. Grabic, P. Gago-Ferrero, T. Gravert, J. Hollender, N. Huynh, G. Jacobs, T. Jonkers, S. Kaserzon, M. Lamoree, J. Le Roux, T. Mairinger, C. Margoum, G. Mascolo, E. Mebold, F. Menger, C. Miège, J. Meijer, R. Moilleron, S. Murgolo, M. Peruzzo, M. Pijnappels, M. Reid, C. Roscioli, C. Soulier, S. Valsecchi, N. Thomaidis, E. Vulliet, R. Young, S. Samanipour, Inter-laboratory mass spectrometry dataset based on passive sampling of drinking water for non-target analysis, Scientific data (2021).
• P. Gago-Ferrero, A. A. Bletsou, D.E. Damalas, R. Aalizadeh, N.A. Alygizakis, H.P. Singer, J. Hollender, N.S. Thomaidis, Wide-scope target screening of >2000 emerging contaminants in wastewater samples with UPLC-Q-ToF-HRMS/MS and smart evaluation of its performance through the validation of 195 selected representative analytes, Journal of Hazardous Materials, Volume 387 (2020).
• P. Rostkowski, P. Haglund, R. Aalizadeh, N. Alygizakis, N. Thomaidis, J. Beltran Arandes, P. Bohlin Nizzetto, P. Booij, H. Budzinski, P. Brunswick, A. Covaci, C. Gallampois, S. Grosse, R, Hindle, I. Ipolyi, K. Jobst, S. L. Kaserzon, P. Leonards, F. Lestremau, T. Letzel, J. Magnér, H. Matsukami, C. Moschet, P. Oswald, M. Plassmann, J. Slobodnik, C. Yang, The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques. Analytical and Bioanalytical Chemistry, Volume 411 (10) (2019).
• N.A. Alygizakis, P. Oswald, N.S. Thomaidis, E.L. Schymanski, R. Aalizadeh, T. Schulze, M. Oswaldova, J. Slobodnik, NORMAN digital sample freezing platform: A European virtual platform to exchange liquid chromatography high resolution-mass spectrometry data and screen suspects in “digitally frozen” environmental samples. TrAC Trends in Analytical Chemistry, Volume 115 (2019).
• J. Hollender, B. van Bavel, V. Dulio, E. Farmen, K. Furtmann, J. Koschorreck, U. Kunkel, M. Krauss, J. Munthe, M. Schlabach, J. Slobodnik, G. Stroomberg, T. Ternes, N. S. Thomaidis, A. Togola and V. Tornero, High resolution mass spectrometry-based non-target screening can support regulatory environmental monitoring and chemicals management, Environmental Sciences Europe (2019).
• N. Alygizakis, S. Samanipour, J. Hollender, M. Ibáñez, S. Kaserzon, V. Kokkali, J. van Leerdam, J. Mueller, M. Pijnappels, M. Reid, E. Schymanski, J. Slobodnik, N. Thomaidis, K. Thomas, Exploring the Potential of a Global Emerging Contaminant Early Warning Network through the use of Retrospective Suspect Screening with High-Resolution Mass Spectrometry, Environ. Sci. Technol, DOI: 10.1021/acs.est.8b00365 (2018).
• J. Hollender, E.L. Schymanski, H. Singer, L. P. Ferguson. Nontarget screening with high resolution mass spectrometry in the environment: ready to go? Environmental science & technology 2017, 51(20):11505–11512 (2017).
• E. L. Schymanski, H. P. Singer, J. Slobodnik, I. M. Ipolyi, P. Oswald, M. Krauss, T. Schulze, P. Haglund, T. Letzel, S. Grosse, N. S. Thomaidis, A. Bletsou, C. Zwiener, M. Ibáñez, T. Portolés, R. de Boer, M. J. Reid, M. Onghena, U. Kunkel, W. Schulz, A. Guillon, N. Noyon, G. Leroy, P. Bados, S. Bogialli, D. Stipaničev, P. Rostkowski, J. Hollender, Non-target screening with high-resolution mass spectrometry: critical review using a collaborative trial on water analysis, Springer (2015).

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